Genome location: Pf3D7_13_v3:1,021,423..1,023,251(+)
Genome classification: Core
Product Description: PRELI domain-containing protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005758 | mitochondrial intermembrane space |
| Component | GO:0005739 | mitochondrion |
| Function | GO:1990050 | phosphatidic acid transfer activity |
| Process | GO:0015914 | phospholipid transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.15 | 0.50 |
| Trophozoite | expressed | 0.45 | 0.73 |
| Schizont | expressed | 0.21 | 0.87 |
| Gametocyte | expressed | 0.35 | 0.79 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1324400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.121 | MFS: -2.925 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IE73
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102353
Most Similar Human Ortholog: Q96N28
TM-align score: 0.93 | RMSD: 1.52
Seq Identity: 0.22 | Length: 171 / 183
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000101166 | PRELI domain containing 3B |
| ENSG00000141391 | PRELI domain containing 3A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 1 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 165
Non-coding: 152 | Synonymous: 9 | Nonsynonymous: 4 | Stop Codon: 0
Protein Length: 183 | Molecular Weight (kDa): 21.689
UniProt ID(s): Q8IE73
PDB ID(s): None
Isoelectric Point: 9.61
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006797 | PRELI/MSF1 domain |
| InterPro | IPR037365 | Slowmo/Ups family |
| PFam | PF04707 | PRELI/MSF1 domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 28168222 | Tg PRELID, a Mitochondrial Protein Linked to Multidrug Resistance in the Parasite Toxoplasma gondii | Jeffers V, Kamau ET, ..., Boyle JP | 10.1128/mSphere.00229-16 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |