About Gene List

PF3D7_1324600

Genome location: Pf3D7_13_v3:1,028,092..1,034,031(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0016020 membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring possibly expressed 0.08 0.96
Trophozoite expressed 0.42 0.76
Schizont expressed 0.14 0.91
Gametocyte expressed 0.99 0.49

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1324600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.889 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IE71

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532517

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 17 71 36 95
disruptive 57 166 109 318
missense 36 121 92 250

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 34 149 76 125
disruptive 108 444 226 435
missense 59 305 162 302

PlasmoDB Total SNPs: 330

Non-coding: 119 | Synonymous: 122 | Nonsynonymous: 88 | Stop Codon: 1

Protein Information

Protein Length: 1661 | Molecular Weight (kDa): 201.043

UniProt ID(s): Q8IE71

PDB ID(s): None

Isoelectric Point: 9.71

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104