PF3D7_1324700 (YKT6.2)

Genome location: Pf3D7_13_v3:1,034,495..1,036,418(+)

Genome classification: Core

Function and Localization

Product Description: SNARE protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0031201	SNARE complex
Function	GO:0005484	SNAP receptor activity
Process	GO:0006886	intracellular protein transport
Process	GO:0031338	regulation of vesicle fusion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.12	0.94
Trophozoite	expressed	0.19	0.88
Schizont	expressed	0.22	0.84
Gametocyte	expressed	0.09	0.94

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1324700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.121 | MFS: -3.22 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1339900)

Relative Growth Rate: 0.28 ± 0.22
Confidence: 4.40

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5D3

"Best" AlphaFill ligand hit: FAR (farnesyl, Local RMSD=0.89) with 6J7F (Global RMSD=3.30)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101684

Most Similar Human Ortholog: A0A7I2V4L6

TM-align score: 0.91 | RMSD: 1.69

Seq Identity: 0.32 | Length: 188 / 221

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000106636	YKT6 v-SNARE homolog

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 113

Non-coding: 111 | Synonymous: 2 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 221 | Molecular Weight (kDa): 25.747

UniProt ID(s): C0H5D3, Q0ZAG4

PDB ID(s): None

Isoelectric Point: 8.44

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001388	Synaptobrevin
InterPro	IPR010908	Longin domain
InterPro	IPR011012	Longin-like domain superfamily
PFam	PF00957	Synaptobrevin
Superfamily	SSF58038	Longin-like domain superfamily
Superfamily	SSF64356