Product Description: phosphoribosylpyrophosphate synthetase
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.7.6.1 (Ribose-phosphate diphosphokinase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005739 | mitochondrion |
| Component | GO:0005634 | nucleus |
| Component | GO:0002189 | ribose phosphate diphosphokinase complex |
| Function | GO:0003723 | RNA binding |
| Function | GO:0004749 | ribose phosphate diphosphokinase activity |
| Process | GO:0006015 | 5-phosphoribose 1-diphosphate biosynthetic process |
| Process | GO:0009165 | nucleotide biosynthetic process |
| Process | GO:0006098 | pentose-phosphate shunt |
| Process | GO:0006164 | purine nucleotide biosynthetic process |
| Process | GO:0006166 | purine ribonucleoside salvage |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.01 | 0.55 |
| Trophozoite | expressed | 1.36 | 0.36 |
| Schizont | expressed | 0.29 | 0.82 |
| Gametocyte | expressed | 0.47 | 0.75 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1325100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.218 | MFS: -2.546 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IE67
"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=0.14) with 6NFE (Global RMSD=1.17)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.7.6.1 | ribose-phosphate diphosphokinase | ATPADPFADUDPAMPGTPGDPCTPUTPUMPGSHGMP... |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P60891 | Ribose-phosphate pyrophosphokinase 1 | Homo sapiens | OMA, OrthoDB | US10981917, Example 1US10981917, Example 2US10981917, Example 4US10981917, Example 5... |
Ortholog Group (OrthoMCL): OG6_100356
Most Similar Human Ortholog: A0A6Q8PHK9
TM-align score: 0.96 | RMSD: 1.23
Seq Identity: 0.50 | Length: 121 / 437
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000101911 | phosphoribosyl pyrophosphate synthetase 2 |
| ENSG00000147224 | phosphoribosyl pyrophosphate synthetase 1 |
| ENSG00000229937 | phosphoribosyl pyrophosphate synthetase 1 like 1 |
Protein Length: 437 | Molecular Weight (kDa): 49.383
UniProt ID(s): Q27726, Q8IE67, Q9U465
PDB ID(s): None
Isoelectric Point: 9.8
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000836 | Phosphoribosyltransferase domain |
| InterPro | IPR005946 | Ribose-phosphate pyrophosphokinase |
| InterPro | IPR029057 | Phosphoribosyltransferase-like |
| InterPro | IPR029099 | Ribose-phosphate pyrophosphokinase, N-terminal domain |
| PFam | PF13793 | Ribose-phosphate pyrophosphokinase, N-terminal domain |
| PFam | PF14572 | Ribose-phosphate pyrophosphokinase |
| Superfamily | SSF53271 | Phosphoribosyltransferase-like |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 31 | 7 | 22 |
| disruptive | 2 | 9 | 9 | 22 |
| missense | 1 | 7 | 6 | 18 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 15 | 52 | 10 | 26 |
| disruptive | 8 | 40 | 15 | 46 |
| missense | 3 | 22 | 11 | 31 |
PlasmoDB Total SNPs: 172
Non-coding: 138 | Synonymous: 29 | Nonsynonymous: 5 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 30204084 | Elucidating the mitochondrial proteome of Toxoplasma gondii reveals the presenceof a divergent cytochrome c oxidase | Seidi A, Muellner-Wong LS, ..., van Dooren GG | 10.7554/eLife.38131 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |