About Gene List

PF3D7_1325300

Genome location: Pf3D7_13_v3:1,050,915..1,051,319(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite no data N/A N/A
Ring no data 0.01 0.99
Trophozoite no data 0.04 0.97
Schizont no data 0.04 0.97
Gametocyte no data 0.66 0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1325300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.97 | MFS: -2.912 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5D4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_160748

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 3 2 4
disruptive 1 4 8 12
missense 1 4 8 12

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 1 6 4 11
disruptive 1 24 10 23
missense 1 21 9 20

PlasmoDB Total SNPs: 5

Non-coding: 0 | Synonymous: 3 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 134 | Molecular Weight (kDa): 16.067

UniProt ID(s): C0H5D4

PDB ID(s): None

Isoelectric Point: 6.89

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

No associated publications