PF3D7_1325400

Genome location: Pf3D7_13_v3:1,052,185..1,063,669(+)

Genome classification: Core

Function and Localization

Product Description: CRWN-like protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0000792	heterochromatin
Component	GO:0005634	nucleus
Function	GO:0003682	chromatin binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.14	0.94
Trophozoite	possibly expressed	1.02	0.54
Schizont	expressed	1.78	0.38
Gametocyte	expressed	1.40	0.35

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1325400

Resistome Missense Mutations: D849H

Resistome Compounds with Missense Mutations: MMV024101

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.848 | #Insertions: 11

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1340500)

Modification: Disrupted | RMgm-3595

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_130329

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	37	140	71	165
disruptive	121	419	251	573
missense	73	342	226	472

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	61	261	128	178
disruptive	258	977	439	923
missense	131	767	346	614

PlasmoDB Total SNPs: 533

Non-coding: 108 | Synonymous: 231 | Nonsynonymous: 194 | Stop Codon: 0

Protein Information

Protein Length: 3519 | Molecular Weight (kDa): 419.083

UniProt ID(s): Q25911, Q8IE65

PDB ID(s): None

Isoelectric Point: 6.74

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108
32017676	The chromatin bound proteome of the human malaria parasite	Batugedara G, Lu XM, ..., Le Roch KG	10.1099/mgen.0.000327