PF3D7_1325500

Genome location: Pf3D7_13_v3:1,063,689..1,066,411(+)

Genome classification: Core

Function and Localization

Product Description: PUA domain-containing protein

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	expressed	0.24	0.85
Schizont	expressed	0.04	0.97
Gametocyte	not expressed	0.10	0.94

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1325500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.939 | MFS: -2.737 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8U8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215370

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	28	19	45
disruptive	5	46	26	103
missense	4	41	23	85

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	57	24	50
disruptive	28	114	84	181
missense	16	83	67	119

PlasmoDB Total SNPs: 212

Non-coding: 117 | Synonymous: 81 | Nonsynonymous: 14 | Stop Codon: 0

Protein Information

Protein Length: 667 | Molecular Weight (kDa): 79.52

UniProt ID(s): A0A5K1K8U8

PDB ID(s): None

Isoelectric Point: 8.97

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR015947	PUA-like superfamily
InterPro	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase
InterPro	IPR041532	RlmI, PUA-like domain
PFam	PF17785	RlmI, PUA-like domain
Superfamily	SSF53335	S-adenosyl-L-methionine-dependent methyltransferase
Superfamily	SSF88697	PUA-like superfamily