Genome location: Pf3D7_13_v3:1,066,876..1,067,829(+)
Genome classification: Core
Product Description: mitochondrial fission 1 protein
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0031307 | integral component of mitochondrial outer membrane |
| Component | GO:0005779 | integral component of peroxisomal membrane |
| Component | GO:0005741 | mitochondrial outer membrane |
| Component | GO:0005739 | mitochondrion |
| Component | GO:0005777 | peroxisome |
| Process | GO:0000422 | autophagy of mitochondrion |
| Process | GO:0000266 | mitochondrial fission |
| Process | GO:0016559 | peroxisome fission |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.00 | 1.00 |
| Trophozoite | expressed | 0.07 | 0.95 |
| Schizont | expressed | 0.19 | 0.86 |
| Gametocyte | expressed | 0.20 | 0.88 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1325600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.632 | MFS: -3.676 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IE63
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 5 | 3 | 8 |
| disruptive | 0 | 3 | 1 | 10 |
| missense | 0 | 3 | 1 | 10 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 10 | 2 | 9 |
| disruptive | 1 | 9 | 14 | 19 |
| missense | 1 | 7 | 12 | 16 |
PlasmoDB Total SNPs: 0
Non-coding: 0 | Synonymous: 0 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 141 | Molecular Weight (kDa): 16.115
UniProt ID(s): Q8IE63
PDB ID(s): None
Isoelectric Point: 8.11
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR011990 | Tetratricopeptide-like helical domain superfamily |
| InterPro | IPR016543 | Mitochondria fission 1 protein |
| InterPro | IPR028061 | Fis1, C-terminal tetratricopeptide repeat |
| InterPro | IPR033745 | Mitochondria fission protein Fis1, cytosolic domain |
| PFam | PF14853 | Fis1, C-terminal tetratricopeptide repeat |
| Superfamily | SSF48452 | Tetratricopeptide-like helical domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 32968006 | Dispensable Role of Mitochondrial Fission Protein 1 (Fis1) in the Erythrocytic Development of Plasmodium falciparum | Maruthi M, Ling L, Zhou J, Ke H | 10.1128/mSphere.00579-20 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 38293973 | [PDCD4 knockdown ameliorates lipopolysaccharide-induced endothelial cell damageby improving mitochondrial dynamics] | Yu J, Li R, ..., Li M | 10.12122/j.issn.1673-4254.2024.01.04 |