PF3D7_1325800

Genome location: Pf3D7_13_v3:1,070,871..1,075,794(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	possibly expressed	0.07	0.97
Trophozoite	expressed	0.27	0.85
Schizont	not expressed	0.07	0.96
Gametocyte	expressed	0.95	0.51

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1325800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.16 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8C9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532960

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	38	26	62
disruptive	48	142	104	225
missense	32	127	96	199

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	93	38	86
disruptive	80	358	188	350
missense	50	300	155	241

PlasmoDB Total SNPs: 219

Non-coding: 35 | Synonymous: 87 | Nonsynonymous: 96 | Stop Codon: 1

Protein Information

Protein Length: 1533 | Molecular Weight (kDa): 185.694

UniProt ID(s): A0A5K1K8C9

PDB ID(s): None

Isoelectric Point: 7.41

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A