PF3D7_1325900

Genome location: Pf3D7_13_v3:1,075,906..1,084,660(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.12	0.94
Trophozoite	expressed	1.01	0.53
Schizont	expressed	0.79	0.64
Gametocyte	expressed	1.21	0.41

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1325900

Resistome Missense Mutations: L1791M, I2686K

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 6 (3 missense, 2 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.571 | #Insertions: 12

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_200821

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	36	88	51	146
disruptive	167	356	189	460
missense	77	256	151	382

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	49	180	103	154
disruptive	267	734	313	683
missense	118	532	262	481

PlasmoDB Total SNPs: 472

Non-coding: 49 | Synonymous: 221 | Nonsynonymous: 202 | Stop Codon: 0

Protein Information

Protein Length: 2756 | Molecular Weight (kDa): 326.142

UniProt ID(s): A0A5K1K8R5

PDB ID(s): None

Isoelectric Point: 6.65

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A