Genome location: Pf3D7_13_v3:1,085,365..1,087,256(-)
Genome classification: Core
Product Description: respiratory chain complex 3 associated protein 2
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0009986 | cell surface |
| Component | GO:0005750 | mitochondrial respiratory chain complex III |
| Component | GO:0005739 | mitochondrion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.02 | 0.99 |
| Trophozoite | possibly expressed | 0.15 | 0.90 |
| Schizont | possibly expressed | 0.30 | 0.81 |
| Gametocyte | not expressed | 0.18 | 0.89 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1326000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.175 | MFS: -2.737 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A5K1K9E9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 11 | 5 | 8 |
| disruptive | 0 | 10 | 5 | 16 |
| missense | 0 | 9 | 5 | 15 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 16 | 6 | 8 |
| disruptive | 4 | 23 | 15 | 43 |
| missense | 3 | 21 | 14 | 28 |
PlasmoDB Total SNPs: 133
Non-coding: 124 | Synonymous: 6 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 163 | Molecular Weight (kDa): 19.285
UniProt ID(s): A0A5K1K9E9
PDB ID(s): None
Isoelectric Point: 9.44
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 27128092 | Interrogating the Plasmodium Sporozoite Surface: Identification ofSurface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP byMass Spectrometry-Based Proteomics. | Swearingen KE, Lindner SE, ..., Sinnis P | 10.1371/journal.ppat.1005606 |
| 33524071 | Divergent features of the coenzyme Q:cytochrome c oxidoreductase complex inToxoplasma gondii parasites. | Hayward JA, Rajendran E, ..., van Dooren GG | 10.1371/journal.ppat.1009211 |
| 34155201 | Composition and stage dynamics of mitochondrial complexes in Plasmodiumfalciparum. | Evers F, Cabrera-Orefice A, ..., Kooij TWA | 10.1038/s41467-021-23919-x |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |