PF3D7_1326100

Genome location: Pf3D7_13_v3:1,087,203..1,090,675(+)

Genome classification: Core

Function and Localization

Product Description: WD repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1326100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.261 | MFS: -2.697 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1341200)

• Relative Growth Rate: 0.40 ± 0.17
• Confidence: 4.92

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1341200)

Modification: Disrupted | RMgm-3597

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8S8

"Best" AlphaFill ligand hit: No AlphaFill hits

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102214

Most Similar Human Ortholog: Q6UXN9

TM-align score: 0.90 | RMSD: 2.15

Seq Identity: 0.18 | Length: 307 / 336

All Human Orthologs (OrthoMCL):

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 170

Non-coding: 151 | Synonymous: 13 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 336 | Molecular Weight (kDa): 39.289

UniProt ID(s): A0A5K1K8S8

PDB ID(s): None

Isoelectric Point: 6.75

Protein Domain Annotations: