PF3D7_1326200

Genome location: Pf3D7_13_v3:1,089,230..1,091,327(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.05	0.98
Trophozoite	no data	0.08	0.94
Schizont	no data	0.04	0.97
Gametocyte	no data	0.25	0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1326200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.121 | MFS: -3.033 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IE58

"Best" AlphaFill ligand hit: PLP (pyridoxal-5'-phosphate, Local RMSD=3.11) with 3K7Y (Global RMSD=17.99)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533592

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	13	9	14
disruptive	9	17	12	33
missense	9	17	12	28

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	25	12	21
disruptive	14	55	32	60
missense	10	44	24	46

PlasmoDB Total SNPs: 21

Non-coding: 8 | Synonymous: 6 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 265 | Molecular Weight (kDa): 32.15

UniProt ID(s): Q8IE58

PDB ID(s): None

Isoelectric Point: 5.3

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A