PF3D7_1326300

Genome location: Pf3D7_13_v3:1,092,355..1,094,980(-)

Genome classification: Core

Function and Localization

Product Description: RNA-binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.43	0.79
Trophozoite	expressed	0.68	0.61
Schizont	expressed	0.18	0.88
Gametocyte	expressed	0.36	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1326300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.222 | MFS: -2.712 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1341500)

Relative Growth Rate: 0.05 ± 0.08
Confidence: 6.36

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K940

"Best" AlphaFill ligand hit: 1PG (2-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethanol, Local RMSD=0.37) with 5W0G (Global RMSD=2.10)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_130126

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	39	20	25
disruptive	54	135	49	98
missense	13	58	32	60

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	17	67	35	39
disruptive	97	197	73	164
missense	28	103	47	90

PlasmoDB Total SNPs: 132

Non-coding: 68 | Synonymous: 38 | Nonsynonymous: 26 | Stop Codon: 0

Protein Information

Protein Length: 527 | Molecular Weight (kDa): 62.882

UniProt ID(s): A0A5K1K940

PDB ID(s): None

Isoelectric Point: 10

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000504	RNA recognition motif domain
InterPro	IPR035979	RNA-binding domain superfamily
PFam	N/A	N/A
Superfamily	SSF54928	RNA-binding domain superfamily