PF3D7_1326500

Genome location: Pf3D7_13_v3:1,099,245..1,106,065(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.10	0.95
Trophozoite	expressed	0.60	0.67
Schizont	expressed	0.29	0.83
Gametocyte	expressed	1.13	0.46

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1326500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.797 | #Insertions: 9

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K847

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533059

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	11	81	45	114
disruptive	86	236	141	336
missense	47	187	116	279

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	23	169	69	142
disruptive	147	536	247	547
missense	66	403	201	374

PlasmoDB Total SNPs: 252

Non-coding: 30 | Synonymous: 132 | Nonsynonymous: 87 | Stop Codon: 3

Protein Information

Protein Length: 2115 | Molecular Weight (kDa): 252.621

UniProt ID(s): A0A5K1K847

PDB ID(s): None

Isoelectric Point: 8.51

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A