PF3D7_1326600

Genome location: Pf3D7_13_v3:1,107,779..1,122,729(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.22	0.90
Trophozoite	possibly expressed	1.56	0.34
Schizont	possibly expressed	0.93	0.56
Gametocyte	not expressed	1.48	0.40

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1326600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.971 | MFS: -2.787 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_115531

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	36	161	100	239
disruptive	241	608	354	837
missense	105	469	305	685

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	76	309	166	288
disruptive	384	1294	579	1176
missense	170	998	458	854

PlasmoDB Total SNPs: 644

Non-coding: 57 | Synonymous: 334 | Nonsynonymous: 252 | Stop Codon: 1

Protein Information

Protein Length: 4780 | Molecular Weight (kDa): 575.463

UniProt ID(s): A0A5K1K8I1

PDB ID(s): None

Isoelectric Point: 9.31

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF141571	N/A