PF3D7_1326700

Genome location: Pf3D7_13_v3:1,125,242..1,127,086(+)

Genome classification: Core

Function and Localization

Product Description: ubiquitin-activating enzyme, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.30	0.85
Trophozoite	no data	0.28	0.83
Schizont	no data	0.39	0.76
Gametocyte	no data	0.67	0.63

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1326700

Resistome Missense Mutations: V73I

Resistome Compounds with Missense Mutations: MMV665794

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.122 | MFS: -3.141 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5E0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_130940

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	14	14	16
disruptive	7	31	20	61
missense	5	25	18	53

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	26	25	29
disruptive	17	108	55	154
missense	8	76	42	88

PlasmoDB Total SNPs: 74

Non-coding: 41 | Synonymous: 29 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 542 | Molecular Weight (kDa): 63.16

UniProt ID(s): C0H5E0

PDB ID(s): None

Isoelectric Point: 10.1

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR035985	Ubiquitin-activating enzyme
PFam	N/A	N/A
Superfamily	SSF69572	Ubiquitin-activating enzyme