About Gene List

PF3D7_1326800 (SYN18)

Genome location: Pf3D7_13_v3:1,127,157..1,128,955(-)

Genome classification: Core

Function and Localization

Product Description: syntaxin, Qa-SNARE family

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0031201 SNARE complex
Component GO:0005783 endoplasmic reticulum
Component GO:0005739 mitochondrion
Function GO:0005484 SNAP receptor activity
Process GO:0006886 intracellular protein transport
Process GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
Process GO:0016192 vesicle-mediated transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite no data N/A N/A
Ring no data 0.06 0.97
Trophozoite no data 0.18 0.88
Schizont no data 0.07 0.95
Gametocyte no data 0.14 0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1326800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.184 | MFS: -3.444 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5E1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_105078

Most Similar Human Ortholog: O75379

TM-align score: 0.57 | RMSD: 3.49

Seq Identity: 0.08 | Length: 111 / 441

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000117533 vesicle associated membrane protein 4

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 17 12 16
disruptive 4 43 23 75
missense 2 37 22 69

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 33 16 22
disruptive 12 114 55 147
missense 5 96 44 108

PlasmoDB Total SNPs: 67

Non-coding: 53 | Synonymous: 6 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 441 | Molecular Weight (kDa): 52.16

UniProt ID(s): C0H5E1, Q0ZAG1

PDB ID(s): None

Isoelectric Point: 8.19

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
17240462 Identification of Plasmodium falciparum family of SNAREs. Ayong L, Pagnotti G, Tobon AB, Chakrabarti D https://pubmed.ncbi.nlm.nih.gov/17240462/
19103232 Plasmodium falciparum secretory pathway: characterization of PfStx1, a plasmamembrane Qa-SNARE. Parish LA, Rayner JC 10.1016/j.molbiopara.2008.11.011
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21