PF3D7_1326900

Genome location: Pf3D7_13_v3:1,129,282..1,133,343(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 5

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus
Function	GO:0050699	WW domain binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.21	0.89
Trophozoite	no data	0.31	0.82
Schizont	no data	0.27	0.85
Gametocyte	no data	1.30	0.42

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1326900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.992 | MFS: -2.808 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5E2

"Best" AlphaFill ligand hit: R78 (4-{[(7r)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-n-(1-methylpiperidin-4-yl)benzamide, Local RMSD=24.17) with 4PY6 (Global RMSD=33.33)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533728

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	44	28	54
disruptive	23	124	71	162
missense	15	89	62	128

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	89	28	72
disruptive	69	252	148	268
missense	38	176	116	174

PlasmoDB Total SNPs: 141

Non-coding: 19 | Synonymous: 72 | Nonsynonymous: 47 | Stop Codon: 3

Protein Information

Protein Length: 1227 | Molecular Weight (kDa): 149.692

UniProt ID(s): C0H5E2

PDB ID(s): None

Isoelectric Point: 6.75

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A