PF3D7_1327000

Genome location: Pf3D7_13_v3:1,133,394..1,138,536(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.36	0.83
Trophozoite	no data	0.79	0.58
Schizont	no data	0.13	0.92
Gametocyte	no data	0.72	0.61

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1327000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.125 | MFS: -3.107 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8S6

"Best" AlphaFill ligand hit: CTP (cytidine-5'-triphosphate, Local RMSD=4.44) with 4FHV (Global RMSD=14.34)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532325

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	38	25	54
disruptive	21	119	76	162
missense	14	107	71	144

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	74	35	67
disruptive	47	224	112	239
missense	27	196	92	196

PlasmoDB Total SNPs: 283

Non-coding: 121 | Synonymous: 91 | Nonsynonymous: 71 | Stop Codon: 0

Protein Information

Protein Length: 1214 | Molecular Weight (kDa): 145.583

UniProt ID(s): A0A5K1K8S6

PDB ID(s): None

Isoelectric Point: 5.18

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR027856	Protein of unknown function DUF4573
PFam	PF15140	Protein of unknown function DUF4573
Superfamily	N/A	N/A