PF3D7_1327100

Genome location: Pf3D7_13_v3:1,138,558..1,141,561(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.01	1.00
Trophozoite	no data	0.00	1.00
Schizont	no data	0.00	1.00
Gametocyte	no data	0.44	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1327100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.484 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1342300)

Relative Growth Rate: 0.94 ± 0.08
Confidence: 6.36

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1342300)

Modification: Disrupted | RMgm-3601

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8V6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_154429

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	11	6	16
disruptive	2	17	15	30
missense	2	17	15	26

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	20	12	13
disruptive	9	53	26	51
missense	4	43	22	42

PlasmoDB Total SNPs: 126

Non-coding: 114 | Synonymous: 8 | Nonsynonymous: 3 | Stop Codon: 1

Protein Information

Protein Length: 344 | Molecular Weight (kDa): 39.905

UniProt ID(s): A0A5K1K8V6

PDB ID(s): None

Isoelectric Point: 7.43

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000922	D-galactoside/L-rhamnose binding SUEL lectin domain
PFam	PF02140	D-galactoside/L-rhamnose binding SUEL lectin domain
Superfamily	N/A	N/A