Genome location: Pf3D7_13_v3:1,145,298..1,152,588(+)
Genome classification: Core
Product Description: subpellicular microtubule protein 3
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0009986 | cell surface |
| Component | GO:0020025 | subpellicular microtubule |
| Process | GO:0000902 | cell morphogenesis |
| Process | GO:0048870 | cell motility |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | possibly expressed | 0.61 | 0.81 |
| Trophozoite | expressed | 0.23 | 0.89 |
| Schizont | expressed | 0.55 | 0.83 |
| Gametocyte | expressed | 2.74 | 0.12 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1327300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.897 | #Insertions: 7
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1342500)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1342500)
Modification: Tagged | RMgm-5265
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A5K1K8E0
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 13 | 48 | 31 | 78 |
| disruptive | 88 | 228 | 104 | 263 |
| missense | 63 | 186 | 92 | 213 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 18 | 95 | 54 | 96 |
| disruptive | 142 | 399 | 167 | 353 |
| missense | 89 | 321 | 140 | 273 |
PlasmoDB Total SNPs: 330
Non-coding: 131 | Synonymous: 88 | Nonsynonymous: 111 | Stop Codon: 0
Protein Length: 1795 | Molecular Weight (kDa): 205.477
UniProt ID(s): A0A5K1K8E0
PDB ID(s): None
Isoelectric Point: 9.91
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 28759593 | Proteogenomic analysis of the total and surface-exposed proteomes of Plasmodiumvivax salivary gland sporozoites. | Swearingen KE, Lindner SE, ..., Mikolajczak SA | https://pubmed.ncbi.nlm.nih.gov/28759593/ |
| 36625655 | A Microtubule-Associated Protein Is Essential for Malaria Parasite Transmission | Wichers-Misterek JS, Binder AM, ..., Gilberger TW | 10.1128/mbio.03318-22 |