About Gene List

PF3D7_1327400

Genome location: Pf3D7_13_v3:1,152,124..1,154,113(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring not expressed 0.09 0.95
Trophozoite possibly expressed 0.71 0.62
Schizont expressed 1.74 0.30
Gametocyte possibly expressed 0.25 0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1327400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.143 | MFS: -2.538 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8S4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532976

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 5 4 5 15
disruptive 5 23 15 48
missense 4 21 14 44

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 15 11 13
disruptive 8 68 27 70
missense 6 54 23 49

PlasmoDB Total SNPs: 71

Non-coding: 60 | Synonymous: 5 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 302 | Molecular Weight (kDa): 36.108

UniProt ID(s): A0A5K1K8S4

PDB ID(s): None

Isoelectric Point: 8.12

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

No associated publications