About Gene List

PF3D7_1327500

Genome location: Pf3D7_13_v3:1,154,684..1,158,545(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005829 cytosol
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.03 0.99
Trophozoite not expressed 0.20 0.88
Schizont not expressed 0.86 0.54
Gametocyte not expressed 0.18 0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1327500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.679 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K9F0

"Best" AlphaFill ligand hit: COA (coenzyme a, Local RMSD=1.49) with 6J0P (Global RMSD=25.07)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_134721

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 8 26 22 24
disruptive 21 59 38 102
missense 21 57 37 90

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 18 43 25 42
disruptive 39 148 74 180
missense 32 116 63 119

PlasmoDB Total SNPs: 220

Non-coding: 165 | Synonymous: 35 | Nonsynonymous: 20 | Stop Codon: 0

Protein Information

Protein Length: 861 | Molecular Weight (kDa): 103.094

UniProt ID(s): A0A5K1K9F0

PDB ID(s): None

Isoelectric Point: 9.66

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
24841368 Identifying novel cell cycle proteins in Apicomplexa parasites throughco-expression decision analysis. Butler CL, Lucas O, ..., White M 10.1371/journal.pone.0097625