PF3D7_1327700 (UPF3B)

Genome location: Pf3D7_13_v3:1,159,359..1,161,728(-)

Genome classification: Core

Function and Localization

Product Description: regulator of nonsense transcripts 3B, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.35	0.83
Trophozoite	no data	0.31	0.81
Schizont	no data	0.05	0.97
Gametocyte	no data	0.50	0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1327700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.988 | MFS: -0.462 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8T6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104140

Most Similar Human Ortholog: Q9BZI7

TM-align score: 0.38 | RMSD: 4.18

Seq Identity: 0.29 | Length: 129 / 271

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000125351	UPF3B regulator of nonsense mediated mRNA decay

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	9	5	11
disruptive	2	20	11	27
missense	2	18	9	23

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	20	8	9
disruptive	11	41	15	58
missense	6	27	8	43

PlasmoDB Total SNPs: 54

Non-coding: 36 | Synonymous: 14 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 271 | Molecular Weight (kDa): 32.437

UniProt ID(s): A0A5K1K8T6

PDB ID(s): None

Isoelectric Point: 9.71

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR005120	UPF3 domain
InterPro	IPR035979	RNA-binding domain superfamily
InterPro	IPR039722	Nonsense-mediated mRNA decay protein 3
PFam	PF03467	UPF3 domain
Superfamily	SSF54928	RNA-binding domain superfamily