PF3D7_1327900

Genome location: Pf3D7_13_v3:1,165,307..1,166,558(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 3.4.25.1 (Proteasome endopeptidase complex)

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.00	1.00
Trophozoite	no data	0.00	1.00
Schizont	no data	0.00	1.00
Gametocyte	no data	0.13	0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1327900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.991 | MFS: -1.869 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZX69

"Best" AlphaFill ligand hit: HEM (heme, Local RMSD=3.42) with 6UNM (Global RMSD=19.39)

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
3.4.25.1	proteasome endopeptidase complex	ATPSDSPSIEDTANH4+EGTATLCKALLNNMDANLVSPI 1PA28...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532720

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	4	2	4
disruptive	4	13	9	25
missense	3	12	7	24

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	9	5	8
disruptive	8	27	15	26
missense	5	26	9	23

PlasmoDB Total SNPs: 25

Non-coding: 20 | Synonymous: 1 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 138 | Molecular Weight (kDa): 16.759

UniProt ID(s): A0A143ZX69

PDB ID(s): None

Isoelectric Point: 4.69

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A