PF3D7_1328000

Genome location: Pf3D7_13_v3:1,173,631..1,181,569(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.13	0.94
Trophozoite	possibly expressed	0.82	0.57
Schizont	expressed	0.34	0.81
Gametocyte	not expressed	1.06	0.53

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1328000

Resistome Missense Mutations: R880I

Resistome Compounds with Missense Mutations: Suloctidil

Resistome # Samples with Disruptive Mutations: 2 (2 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.967 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K950

"Best" AlphaFill ligand hit: SIS ((1s,2s,3r,4s,6r)-4,6-diamino-3-{[(2s,3r)-3-amino-6-(aminomethyl)-3,4-dihydro-2h-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-c-methyl-3-(methylamino)-beta-l-arabinopyranoside, Local RMSD=0.98) with 5C4L (Global RMSD=36.83)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533556

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	82	61	108
disruptive	40	208	122	341
missense	28	190	115	303

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	21	182	70	122
disruptive	91	476	208	412
missense	57	403	184	322

PlasmoDB Total SNPs: 165

Non-coding: 40 | Synonymous: 76 | Nonsynonymous: 49 | Stop Codon: 0

Protein Information

Protein Length: 2213 | Molecular Weight (kDa): 261.45

UniProt ID(s): A0A5K1K950

PDB ID(s): None

Isoelectric Point: 9.52

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A