PF3D7_1328200

Genome location: Pf3D7_13_v3:1,186,514..1,196,153(+)

Genome classification: Core

Function and Localization

Product Description: BRCA2 protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.10	0.95
Trophozoite	possibly expressed	0.65	0.66
Schizont	expressed	0.93	0.54
Gametocyte	not expressed	0.64	0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1328200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.256 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PbANKA_1343400)

Modification: Disrupted | RMgm-5220

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K982

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532725

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	29	101	42	146
disruptive	76	300	205	433
missense	65	252	185	388

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	43	185	95	144
disruptive	138	687	291	628
missense	99	580	249	455

PlasmoDB Total SNPs: 428

Non-coding: 178 | Synonymous: 143 | Nonsynonymous: 107 | Stop Codon: 0

Protein Information

Protein Length: 2668 | Molecular Weight (kDa): 320.136

UniProt ID(s): A0A5K1K982

PDB ID(s): None

Isoelectric Point: 7.55

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A