About Gene List

PF3D7_1328300

Genome location: Pf3D7_13_v3:1,195,364..1,199,554(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0016020 membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.21 0.90
Trophozoite expressed 0.52 0.69
Schizont expressed 1.05 0.45
Gametocyte expressed 0.31 0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1328300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.121 | MFS: -3.035 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1343500)

  • Relative Growth Rate: 0.60 ± 0.42
  • Confidence: 3.11

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1343500)

Modification: Disrupted | RMgm-3607

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IE43

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533735

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 0 0 0
disruptive 0 1 0 1
missense 0 0 0 0

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 0 0 0 0
disruptive 0 1 0 1
missense 0 0 0 0

PlasmoDB Total SNPs: 253

Non-coding: 242 | Synonymous: 6 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 332 | Molecular Weight (kDa): 38.776

UniProt ID(s): Q8IE43

PDB ID(s): None

Isoelectric Point: 6.51

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104