About Gene List

PF3D7_1328400

Genome location: Pf3D7_13_v3:1,199,670..1,202,958(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0016020 membrane
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring not expressed 0.14 0.93
Trophozoite expressed 0.47 0.73
Schizont not expressed 0.07 0.96
Gametocyte expressed 0.35 0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1328400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.122 | MFS: -3.009 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1343600)

  • Relative Growth Rate: 0.07 ± 0.11
  • Confidence: 5.85

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5E6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_122822

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 10 13 25
disruptive 28 70 32 79
missense 19 53 29 57

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 35 15 37
disruptive 47 158 84 163
missense 29 109 52 100

PlasmoDB Total SNPs: 180

Non-coding: 121 | Synonymous: 31 | Nonsynonymous: 28 | Stop Codon: 0

Protein Information

Protein Length: 500 | Molecular Weight (kDa): 60.307

UniProt ID(s): C0H5E6

PDB ID(s): None

Isoelectric Point: 10.44

Protein Domain Annotations:

Source Family ID Description
InterPro IPR009688 Domain of unknown function DUF1279
PFam PF06916 Domain of unknown function DUF1279
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21