About Gene List

PF3D7_1328500

Genome location: Pf3D7_13_v3:1,203,340..1,208,913(-)

Genome classification: Core

Function and Localization

Product Description: alpha/beta-hydrolase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.48 0.80
Trophozoite expressed 0.54 0.69
Schizont expressed 0.37 0.78
Gametocyte expressed 0.28 0.83

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1328500

Resistome Missense Mutations: K851N

Resistome Compounds with Missense Mutations: Halofuginone

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.416 | #Insertions: 9

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K859

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_157547

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 5 33 19 47
disruptive 23 145 65 190
missense 14 94 49 138

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 11 67 38 71
disruptive 74 312 148 315
missense 35 213 100 182

PlasmoDB Total SNPs: 373

Non-coding: 205 | Synonymous: 95 | Nonsynonymous: 73 | Stop Codon: 0

Protein Information

Protein Length: 1004 | Molecular Weight (kDa): 115.89

UniProt ID(s): A0A5K1K859

PDB ID(s): None

Isoelectric Point: 5.63

Protein Domain Annotations:

Source Family ID Description
InterPro IPR022742 Serine aminopeptidase, S33
InterPro IPR029058 Alpha/Beta hydrolase fold
PFam PF12146 Serine aminopeptidase, S33
Superfamily SSF53474 Alpha/Beta hydrolase fold

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104