Product Description: alpha/beta-hydrolase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB): None
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | not expressed | N/A | N/A |
Ring | expressed | 0.48 | 0.80 |
Trophozoite | expressed | 0.54 | 0.69 |
Schizont | expressed | 0.37 | 0.78 |
Gametocyte | expressed | 0.28 | 0.83 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1328500
Resistome Missense Mutations: K851N
Resistome Compounds with Missense Mutations: Halofuginone
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.416 | #Insertions: 9
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A5K1K859
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 5 | 33 | 19 | 47 |
disruptive | 23 | 145 | 65 | 190 |
missense | 14 | 94 | 49 | 138 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 11 | 67 | 38 | 71 |
disruptive | 74 | 312 | 148 | 315 |
missense | 35 | 213 | 100 | 182 |
PlasmoDB Total SNPs: 373
Non-coding: 205 | Synonymous: 95 | Nonsynonymous: 73 | Stop Codon: 0
Protein Length: 1004 | Molecular Weight (kDa): 115.89
UniProt ID(s): A0A5K1K859
PDB ID(s): None
Isoelectric Point: 5.63
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR022742 | Serine aminopeptidase, S33 |
InterPro | IPR029058 | Alpha/Beta hydrolase fold |
PFam | PF12146 | Serine aminopeptidase, S33 |
Superfamily | SSF53474 | Alpha/Beta hydrolase fold |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |