PF3D7_1328600

Genome location: Pf3D7_13_v3:1,209,744..1,211,772(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.16	0.92
Trophozoite	not expressed	0.07	0.96
Schizont	not expressed	0.04	0.97
Gametocyte	expressed	0.39	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1328600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.521 | MFS: -2.678 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5E7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533211

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	9	9	24
disruptive	4	33	16	34
missense	4	32	15	31

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	29	13	24
disruptive	14	80	31	73
missense	10	66	27	49

PlasmoDB Total SNPs: 92

Non-coding: 78 | Synonymous: 8 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 363 | Molecular Weight (kDa): 43.331

UniProt ID(s): C0H5E7

PDB ID(s): None

Isoelectric Point: 6.5

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A