About Gene List

PF3D7_1329200

Genome location: Pf3D7_13_v3:1,236,406..1,238,812(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.07 0.96
Trophozoite not expressed 0.12 0.92
Schizont not expressed 0.07 0.95
Gametocyte not expressed 0.26 0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1329200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 1.454 | #Insertions: 3

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1344200)

  • Relative Growth Rate: 1.00 ± 0.08
  • Confidence: 6.38

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1344200)

Modification: Disrupted | RMgm-3611

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IE51

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_121099

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 9 8 9
disruptive 2 24 18 43
missense 2 24 16 37

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 5 20 12 9
disruptive 9 62 29 61
missense 7 50 22 40

PlasmoDB Total SNPs: 133

Non-coding: 121 | Synonymous: 5 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 270 | Molecular Weight (kDa): 31.757

UniProt ID(s): Q8IE51

PDB ID(s): None

Isoelectric Point: 8.96

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
17653272 Rapid identification of malaria vaccine candidates based on alpha-helical coiledcoil protein motif. Villard V, Agak GW, ..., Corradin G 10.1371/journal.pone.0000645