About Gene List

PF3D7_1329500

Genome location: Pf3D7_13_v3:1,250,030..1,258,393(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 2.26 0.23
Trophozoite expressed 0.90 0.54
Schizont expressed 0.47 0.74
Gametocyte expressed 0.66 0.65

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1329500

Resistome Missense Mutations: F545S, I550T, N555K, T556I, S557F

Resistome Compounds with Missense Mutations: Cipargamin/KAE609/NITD609, Proguanil

Resistome # Samples with Disruptive Mutations: 15 (15 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.283 | MFS: -2.663 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1344500)

  • Relative Growth Rate: 0.13 ± 0.40
  • Confidence: 3.20

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8J1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_158744

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 23 94 39 126
disruptive 69 197 116 291
missense 39 153 90 230

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 38 219 82 146
disruptive 131 491 262 636
missense 72 362 187 370

PlasmoDB Total SNPs: 537

Non-coding: 354 | Synonymous: 115 | Nonsynonymous: 68 | Stop Codon: 0

Protein Information

Protein Length: 1844 | Molecular Weight (kDa): 218.438

UniProt ID(s): A0A5K1K8J1

PDB ID(s): None

Isoelectric Point: 8.18

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108