PF3D7_1329600

Genome location: Pf3D7_13_v3:1,258,409..1,260,377(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	2.07	0.23
Trophozoite	possibly expressed	1.29	0.38
Schizont	possibly expressed	0.41	0.76
Gametocyte	possibly expressed	0.87	0.55

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1329600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 1 | MFS: -1.598 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8T4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533358

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	8	6	13
disruptive	15	33	19	38
missense	6	27	14	33

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	27	6	15
disruptive	28	90	41	89
missense	8	66	32	54

PlasmoDB Total SNPs: 114

Non-coding: 54 | Synonymous: 19 | Nonsynonymous: 41 | Stop Codon: 0

Protein Information

Protein Length: 301 | Molecular Weight (kDa): 35.019

UniProt ID(s): A0A5K1K8T4

PDB ID(s): None

Isoelectric Point: 7.09

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A