Genome location: Pf3D7_13_v3:1,260,632..1,263,601(-)
Genome classification: Core
Product Description: apicoplast calcium binding protein 1
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | not expressed | 0.02 | 0.99 |
| Trophozoite | not expressed | 0.03 | 0.98 |
| Schizont | expressed | 0.30 | 0.85 |
| Gametocyte | expressed | 1.21 | 0.45 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1329700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: 0.369 | #Insertions: 3
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A5K1K8W4
"Best" AlphaFill ligand hit: UDP (uridine-5'-diphosphate, Local RMSD=2.87) with 6OQ7 (Global RMSD=24.30)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 31 | 13 | 40 |
| disruptive | 26 | 76 | 31 | 91 |
| missense | 8 | 50 | 23 | 73 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 63 | 25 | 43 |
| disruptive | 63 | 134 | 80 | 174 |
| missense | 22 | 99 | 59 | 111 |
PlasmoDB Total SNPs: 260
Non-coding: 188 | Synonymous: 47 | Nonsynonymous: 25 | Stop Codon: 0
Protein Length: 532 | Molecular Weight (kDa): 64.035
UniProt ID(s): A0A5K1K8W4
PDB ID(s): None
Isoelectric Point: 9.26
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002048 | EF-hand domain |
| InterPro | IPR011992 | EF-hand domain pair |
| InterPro | IPR018247 | EF-Hand 1, calcium-binding site |
| PFam | PF13499 | EF-hand domain |
| Superfamily | SSF47473 | EF-hand domain pair |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 24877144 | Role of calcium signaling in the transcriptional regulation of the apicoplastgenome of Plasmodium falciparum. | Cheemadan S, Ramadoss R, Bozdech Z | 10.1155/2014/869401 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |
| 30362657 | Synergistic roles of acyl-CoA binding protein (ACBP1) and sterol carrier protein2 (SCP2) in Toxoplasma lipid metabolism | Fu Y, Cui X, ..., Liu Q | 10.1111/cmi.12970 |