PF3D7_1329800

Genome location: Pf3D7_13_v3:1,264,495..1,269,102(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.08	0.96
Trophozoite	possibly expressed	0.26	0.84
Schizont	possibly expressed	0.19	0.89
Gametocyte	not expressed	0.25	0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1329800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.884 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8F0

"Best" AlphaFill ligand hit: U5P (uridine-5'-monophosphate, Local RMSD=7.82) with 6DSR (Global RMSD=13.46)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_127564

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	20	46	28	74
disruptive	56	168	90	209
missense	36	134	77	182

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	26	98	45	75
disruptive	88	352	167	330
missense	54	286	124	217

PlasmoDB Total SNPs: 293

Non-coding: 123 | Synonymous: 95 | Nonsynonymous: 75 | Stop Codon: 0

Protein Information

Protein Length: 1208 | Molecular Weight (kDa): 144.294

UniProt ID(s): A0A5K1K8F0

PDB ID(s): None

Isoelectric Point: 9.12

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A