PF3D7_1329900

Genome location: Pf3D7_13_v3:1,269,178..1,271,461(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.09	0.95
Trophozoite	expressed	0.29	0.83
Schizont	possibly expressed	0.08	0.95
Gametocyte	expressed	0.67	0.64

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1329900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.125 | MFS: -3.137 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1344900)

Relative Growth Rate: 0.11 ± 0.04
Confidence: 7.86

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8T3

"Best" AlphaFill ligand hit: U5P (uridine-5'-monophosphate, Local RMSD=0.17) with 6DSR (Global RMSD=22.40)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533715

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	21	14	40
disruptive	29	92	53	120
missense	18	69	40	88

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	60	31	43
disruptive	51	220	84	196
missense	30	151	60	115

PlasmoDB Total SNPs: 130

Non-coding: 20 | Synonymous: 50 | Nonsynonymous: 60 | Stop Codon: 0

Protein Information

Protein Length: 707 | Molecular Weight (kDa): 85.276

UniProt ID(s): A0A5K1K8T3

PDB ID(s): None

Isoelectric Point: 9.86

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A