PF3D7_1330000

Genome location: Pf3D7_13_v3:1,271,713..1,273,859(+)

Genome classification: Core

Function and Localization

Product Description: PITH domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	nd	nd
Trophozoite	expressed	nd	nd
Schizont	possibly expressed	nd	nd
Gametocyte	expressed	nd	nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1330000.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.228 | MFS: -2.576 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IE26

"Best" AlphaFill ligand hit: PUT (putrescine, Local RMSD=0.78) with 6QMM (Global RMSD=14.10)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102988

Most Similar Human Ortholog: X6RHB9

TM-align score: 0.80 | RMSD: 2.04

Seq Identity: 0.23 | Length: 69 / 206

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000057757	PITH domain containing 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	11	4	9
disruptive	1	14	13	25
missense	1	13	13	24

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	19	9	9
disruptive	2	42	23	58
missense	2	36	22	48

PlasmoDB Total SNPs: 107

Non-coding: 93 | Synonymous: 12 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 206 | Molecular Weight (kDa): 23.317

UniProt ID(s): Q8IE26

PDB ID(s): None

Isoelectric Point: 5.88

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR008979	Galactose-binding-like domain superfamily
InterPro	IPR010400	PITH domain
PFam	PF06201	PITH domain
Superfamily	SSF49785	Galactose-binding-like domain superfamily