PF3D7_1330400

Genome location: Pf3D7_13_v3:1,278,881..1,281,897(-)

Genome classification: Core

Function and Localization

Product Description: ER lumen protein retaining receptor 1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 8

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005794	Golgi apparatus
Component	GO:0005801	cis-Golgi network
Component	GO:0005783	endoplasmic reticulum
Function	GO:0046923	ER retention sequence binding
Function	GO:0045015	HDEL sequence binding
Process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport
Process	GO:0006621	protein retention in ER lumen

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	nd	nd
Trophozoite	expressed	nd	nd
Schizont	expressed	nd	nd
Gametocyte	expressed	nd	nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1330400.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.128 | MFS: -3.029 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1345400)

Relative Growth Rate: 0.04 ± 0.09
Confidence: 6.15

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IE22

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_108960

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	9	3	23
disruptive	0	3	3	9
missense	0	3	2	8

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	33	9	22
disruptive	0	20	16	59
missense	0	13	10	31

PlasmoDB Total SNPs: 151

Non-coding: 141 | Synonymous: 9 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 284 | Molecular Weight (kDa): 32.806

UniProt ID(s): Q8IE22

PDB ID(s): None

Isoelectric Point: 7.28

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000133	ER lumen protein retaining receptor
PFam	PF00810	ER lumen protein retaining receptor
Superfamily	N/A	N/A