PF3D7_1330700

Genome location: Pf3D7_13_v3:1,289,960..1,293,507(+)

Genome classification: Core

Function and Localization

Product Description: GPI transamidase subunit PIG-U, putative

SignalP Peptide: N/A

# Transmembrane Domains: 10

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0016020	membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.05	0.98
Trophozoite	expressed	0.44	0.73
Schizont	expressed	0.22	0.86
Gametocyte	expressed	0.47	0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1330700

Resistome Missense Mutations: A488S, A488V, L489F

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.143 | MFS: -3.113 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1345700)

Relative Growth Rate: 0.20 ± 0.26
Confidence: 4.11

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K957

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_206085

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	29	26	29
disruptive	9	37	28	80
missense	9	34	26	75

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	59	29	50
disruptive	19	106	53	139
missense	19	81	46	102

PlasmoDB Total SNPs: 203

Non-coding: 162 | Synonymous: 28 | Nonsynonymous: 13 | Stop Codon: 0

Protein Information

Protein Length: 611 | Molecular Weight (kDa): 73.684

UniProt ID(s): A0A5K1K957

PDB ID(s): None

Isoelectric Point: 10.03

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR009600	GPI transamidase subunit PIG-U
PFam	PF06728	N/A
Superfamily	N/A	N/A