Product Description: RNA-binding protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0061574 | ASAP complex |
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005654 | nucleoplasm |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003729 | mRNA binding |
| Process | GO:0008380 | RNA splicing |
| Process | GO:0000398 | mRNA splicing, via spliceosome |
| Process | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.90 | 0.27 |
| Trophozoite | expressed | 1.74 | 0.27 |
| Schizont | expressed | 0.40 | 0.78 |
| Gametocyte | expressed | 1.33 | 0.38 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1330800
Resistome Missense Mutations: C480F
Resistome Compounds with Missense Mutations: DDD01061024
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.908 | MFS: -2.242 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1345800)
Modification: Disrupted | RMgm-3618
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IE18
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 18 | 60 | 21 | 43 |
| disruptive | 47 | 141 | 72 | 130 |
| missense | 17 | 61 | 43 | 82 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 35 | 87 | 29 | 44 |
| disruptive | 86 | 237 | 116 | 223 |
| missense | 31 | 119 | 73 | 123 |
PlasmoDB Total SNPs: 314
Non-coding: 210 | Synonymous: 67 | Nonsynonymous: 37 | Stop Codon: 0
Protein Length: 596 | Molecular Weight (kDa): 68.01
UniProt ID(s): Q8IE18
PDB ID(s): None
Isoelectric Point: 4.88
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000504 | RNA recognition motif domain |
| InterPro | IPR035979 | RNA-binding domain superfamily |
| PFam | PF00076 | RNA recognition motif domain |
| Superfamily | SSF54928 | RNA-binding domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 27381095 | The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. | Bunnik EM, Batugedara G, ..., Le Roch KG | 10.1186/s13059-016-1014-0 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |