PF3D7_1331000

Genome location: Pf3D7_13_v3:1,297,070..1,299,355(-)

Genome classification: Core

Function and Localization

Product Description: protein kinase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	possibly expressed	0.23	0.89
Trophozoite	expressed	0.18	0.89
Schizont	expressed	0.53	0.73
Gametocyte	expressed	0.13	0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1331000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.714 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IE17

"Best" AlphaFill ligand hit: R78 (4-{[(7r)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-n-(1-methylpiperidin-4-yl)benzamide, Local RMSD=0.23) with 4I5M (Global RMSD=7.53)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_135496

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	15	6	45
disruptive	16	60	40	97
missense	14	59	37	85

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	44	22	43
disruptive	36	127	58	142
missense	31	106	55	100

PlasmoDB Total SNPs: 92

Non-coding: 38 | Synonymous: 26 | Nonsynonymous: 27 | Stop Codon: 1

Protein Information

Protein Length: 557 | Molecular Weight (kDa): 66.864

UniProt ID(s): Q8IE17

PDB ID(s): None

Isoelectric Point: 8.63

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000719	Protein kinase domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain superfamily
PFam	PF07714	Serine-threonine/tyrosine-protein kinase, catalytic domain
Superfamily	SSF56112	Protein kinase-like domain superfamily