PF3D7_1331200

Genome location: Pf3D7_13_v3:1,305,681..1,308,163(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.44	0.79
Trophozoite	expressed	0.58	0.67
Schizont	expressed	0.34	0.79
Gametocyte	possibly expressed	0.55	0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1331200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.216 | MFS: -2.674 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1346100)

Relative Growth Rate: 0.80 ± 0.34
Confidence: 3.55

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1346100)

Modification: Disrupted | RMgm-4286

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K984

"Best" AlphaFill ligand hit: 144 (tris-hydroxymethyl-methyl-ammonium, Local RMSD=10.77) with 5NPY (Global RMSD=18.53)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532634

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	27	12	26
disruptive	14	50	38	76
missense	8	35	36	58

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	48	22	26
disruptive	49	139	70	161
missense	17	99	47	88

PlasmoDB Total SNPs: 152

Non-coding: 100 | Synonymous: 32 | Nonsynonymous: 20 | Stop Codon: 0

Protein Information

Protein Length: 407 | Molecular Weight (kDa): 48.617

UniProt ID(s): A0A5K1K984

PDB ID(s): None

Isoelectric Point: 5.22

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A