Genome location: Pf3D7_13_v3:1,308,678..1,310,348(+)
Genome classification: Core
Product Description: signal peptidase complex catalytic subunit SEC11
SignalP Peptide: N/A
# Transmembrane Domains: 3
EC Numbers: 3.4.21.89 (Signal peptidase I)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0005787 | signal peptidase complex |
| Function | GO:0008233 | peptidase activity |
| Function | GO:0005515 | protein binding |
| Process | GO:0006465 | signal peptide processing |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | possibly expressed | 0.01 | 0.99 |
| Trophozoite | expressed | 0.14 | 0.90 |
| Schizont | expressed | 0.08 | 0.94 |
| Gametocyte | expressed | 0.08 | 0.95 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1331300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.159 | MFS: -2.822 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1346200)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IE14
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.4.21.89 | Signal peptidase I | NEMSDSEDTAMG132cholateantipainL685,458rifampicinBAL0019193arylomycinlactacystindeoxycholate... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100807
Most Similar Human Ortholog: H0YNX5
TM-align score: 0.90 | RMSD: 1.45
Seq Identity: 0.55 | Length: 104 / 184
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000140612 | SEC11 homolog A, signal peptidase complex subunit |
| ENSG00000166562 | SEC11 homolog C, signal peptidase complex subunit |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 6 | 4 | 10 |
| disruptive | 6 | 5 | 1 | 6 |
| missense | 6 | 4 | 1 | 6 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 15 | 6 | 6 |
| disruptive | 9 | 7 | 6 | 30 |
| missense | 8 | 6 | 4 | 22 |
PlasmoDB Total SNPs: 135
Non-coding: 118 | Synonymous: 11 | Nonsynonymous: 4 | Stop Codon: 2
Protein Length: 184 | Molecular Weight (kDa): 21.125
UniProt ID(s): Q2V8J6, Q2V8J7, Q8IE14
PDB ID(s): None
Isoelectric Point: 6.91
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001733 | Peptidase S26B |
| InterPro | IPR015927 | Peptidase S24/S26A/S26B/S26C |
| InterPro | IPR019758 | Peptidase S26A, signal peptidase I, conserved site |
| InterPro | IPR036286 | LexA/Signal peptidase-like superfamily |
| PFam | PF00717 | Peptidase S24/S26A/S26B/S26C |
| Superfamily | SSF51306 | LexA/Signal peptidase-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16873890 | Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 andmalaria signal peptide peptidase. | Nyborg AC, Ladd TB, ..., Golde TE | 10.1096/fj.06-5762com |
| 18054093 | Plasmodium falciparum signal peptidase is regulated by phosphorylation andrequired for intra-erythrocytic growth. | Tuteja R, Pradhan A, Sharma S | 10.1016/j.molbiopara.2007.10.007 |
| 30127496 | Plasmepsin V cleaves malaria effector proteins in a distinct endoplasmicreticulum translocation interactome for export to the erythrocyte. | Marapana DS, Dagley LF, ..., Cowman AF | 10.1038/s41564-018-0219-2 |
| 11058593 | Signal peptidase and oligosaccharyltransferase interact in a sequential anddependent manner within the endoplasmic reticulum | Chen X, VanValkenburgh C, ..., Green N | 10.1074/jbc.M007723200 |
| 20559436 | Characterization of yeast extracellular vesicles: evidence for the participationof different pathways of cellular traffic in vesicle biogenesis | Oliveira DL, Nakayasu ES, ..., Rodrigues ML | 10.1371/journal.pone.0011113 |
| 10601196 | Localization of synthesis of beta1,6-glucan in Saccharomyces cerevisiae | Montijn RC, Vink E, ..., Klis FM | 10.1128/JB.181.24.7414-7420.1999 |
| 11886564 | Interactions of the Trichoderma reesei rho3 with the secretory pathway in yeastand T. reesei | Vasara T, Salusjarvi L, ..., Saloheimo M | 10.1046/j.1365-2958.2001.02716.x |
| 11038189 | Ordering the final events in yeast exocytosis | Grote E, Carr CM, Novick PJ | 10.1083/jcb.151.2.439 |
| 16087665 | Mso1 is a novel component of the yeast exocytic SNARE complex | Castillo-Flores A, Weinberger A, Robinson M, Gerst JE | 10.1074/jbc.M507142200 |
| 15300682 | Characterization of Candida albicans orthologue of the Saccharomyces cerevisiaesignal-peptidase-subunit encoding gene SPC3 | De La Rosa JM, Gonzalez JM, ..., Rodriguez L | 10.1002/yea.1137 |