PF3D7_1331400

Genome location: Pf3D7_13_v3:1,310,771..1,312,216(+)

Genome classification: Core

Function and Localization

Product Description: CPW-WPC family protein

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	possibly expressed	0.02	0.99
Trophozoite	possibly expressed	0.07	0.95
Schizont	expressed	0.09	0.94
Gametocyte	expressed	0.43	0.83

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1331400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.925 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1346300)

Relative Growth Rate: 1.02 ± 0.11
Confidence: 5.88

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1346300)

Modification: Disrupted | RMgm-3621

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K873

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_125525

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	14	16	29
disruptive	9	27	22	48
missense	8	27	22	46

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	42	24	29
disruptive	16	81	41	113
missense	15	67	36	79

PlasmoDB Total SNPs: 12

Non-coding: 0 | Synonymous: 3 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 481 | Molecular Weight (kDa): 56.311

UniProt ID(s): A0A5K1K873

PDB ID(s): None

Isoelectric Point: 7.09

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006387	CPW-WPC domain
PFam	PF09717	CPW-WPC domain
Superfamily	N/A	N/A