PF3D7_1331500

Genome location: Pf3D7_13_v3:1,313,440..1,316,380(+)

Genome classification: Core

Function and Localization

Product Description: ATF7-int domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.15	0.92
Trophozoite	not expressed	0.19	0.88
Schizont	not expressed	0.52	0.76
Gametocyte	not expressed	0.20	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1331500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.339 | MFS: -2.627 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1346400)

Modification: Disrupted | RMgm-3622

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8J9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

Orthology to BindingDB Entries:

UniProt	Protein Name	Species	Homology Source	BindingDB Ligands
P0C6X4	Replicase polyprotein 1ab		OrthoMCL BLAST	cmdc.202100576, 6bUS9975885, Compound 6US9975885, Compound 13US9975885, Compound 14...

Orthology Information

Ortholog Group (OrthoMCL): OG6_533533

No human ortholog(s)

Protein Information

Protein Length: 620 | Molecular Weight (kDa): 73.705

UniProt ID(s): A0A5K1K8J9

PDB ID(s): None

Isoelectric Point: 4.74

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR026085	Activating transcription factor 7-interacting protein
PFam	N/A	N/A
Superfamily	N/A	N/A

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	17	12	32
disruptive	25	74	39	109
missense	19	54	34	93

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	38	24	41
disruptive	49	177	70	164
missense	29	122	55	118

PlasmoDB Total SNPs: 282

Non-coding: 135 | Synonymous: 78 | Nonsynonymous: 69 | Stop Codon: 0