Product Description: 60S ribosomal protein L23, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022625 | cytosolic large ribosomal subunit |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0070180 | large ribosomal subunit rRNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.65 | 0.70 |
| Trophozoite | expressed | 0.86 | 0.56 |
| Schizont | expressed | 0.13 | 0.91 |
| Gametocyte | expressed | 0.48 | 0.72 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1331800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.126 | MFS: -2.947 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1346700)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IE09
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100370
Most Similar Human Ortholog: J3KTJ3
TM-align score: 0.97 | RMSD: 0.61
Seq Identity: 0.69 | Length: 81 / 139
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000125691 | ribosomal protein L23 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 8 | 5 | 6 |
| disruptive | 0 | 0 | 0 | 5 |
| missense | 0 | 0 | 0 | 4 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 13 | 3 | 10 |
| disruptive | 1 | 9 | 6 | 14 |
| missense | 0 | 6 | 5 | 9 |
PlasmoDB Total SNPs: 125
Non-coding: 118 | Synonymous: 7 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 139 | Molecular Weight (kDa): 14.993
UniProt ID(s): Q8IE09
PDB ID(s): 3J79, 3JBN, 3JBO, 3JBP, 5UMD
Isoelectric Point: 10.47
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000218 | Ribosomal protein L14P |
| InterPro | IPR036853 | Ribosomal protein L14 superfamily |
| PFam | PF00238 | Ribosomal protein L14P |
| Superfamily | SSF50193 | Ribosomal protein L14 superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 24913268 | Cryo-E M structure of the Plasmodium falciparum 80 S ribosome bound to theanti-protozoan drug emetine | Wong W, Bai XC, ..., Scheres SH | 10.7554/eLife.03080 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |