Genome location: Pf3D7_13_v3:1,325,849..1,328,634(-)
Genome classification: Core
Product Description: syntaxin, Qa-SNARE family
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000139 | Golgi membrane |
| Component | GO:0031201 | SNARE complex |
| Component | GO:0005801 | cis-Golgi network |
| Component | GO:0012505 | endomembrane system |
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0016021 | integral component of membrane |
| Function | GO:0005484 | SNAP receptor activity |
| Function | GO:0000149 | SNARE binding |
| Process | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| Process | GO:0006886 | intracellular protein transport |
| Process | GO:0048278 | vesicle docking |
| Process | GO:0006906 | vesicle fusion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.04 | 0.98 |
| Trophozoite | not expressed | 0.07 | 0.95 |
| Schizont | not expressed | 0.10 | 0.93 |
| Gametocyte | not expressed | 0.11 | 0.93 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1332000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -2.83 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1346800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IE08
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102103
Most Similar Human Ortholog: H7C3X5
TM-align score: 0.78 | RMSD: 2.55
Seq Identity: 0.32 | Length: 196 / 281
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000162236 | syntaxin 5 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 220
Non-coding: 212 | Synonymous: 6 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 281 | Molecular Weight (kDa): 32.811
PDB ID(s): None
Isoelectric Point: 7.29
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000727 | Target SNARE coiled-coil homology domain |
| InterPro | IPR010989 | SNARE |
| PFam | PF05739 | Target SNARE coiled-coil homology domain |
| Superfamily | SSF47661 | SNARE |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 17240462 | Identification of Plasmodium falciparum family of SNAREs. | Ayong L, Pagnotti G, Tobon AB, Chakrabarti D | https://pubmed.ncbi.nlm.nih.gov/17240462/ |