PF3D7_1332100

Genome location: Pf3D7_13_v3:1,329,491..1,331,059(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 11

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.01	0.99
Schizont	expressed	0.02	0.98
Gametocyte	expressed	0.02	0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1332100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.139 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IE07

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_113078

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	20	18	27
disruptive	9	67	50	99
missense	8	65	46	91

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	47	17	43
disruptive	13	152	69	145
missense	10	142	60	118

PlasmoDB Total SNPs: 38

Non-coding: 0 | Synonymous: 21 | Nonsynonymous: 17 | Stop Codon: 0

Protein Information

Protein Length: 522 | Molecular Weight (kDa): 61.247

UniProt ID(s): Q8IE07

PDB ID(s): None

Isoelectric Point: 8.08

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR008537	Protein of unknown function DUF819
PFam	PF05684	Protein of unknown function DUF819
Superfamily	N/A	N/A